Lipid Profile variation in subclinical and clinical Hypothyroidism and their correlation with BMI.
Main Article Content
Abstract
Objective: The present study aimed to compare the variation in lipid profiles between patients with subclinical and clinical
hypothyroidism and their correlation with BMI.
Methodology: A cross-sectional study carried out on 120 patients (aged 20-60 years) in the Department of Medicine,
Pakistan Institute of Medical Science, Islamabad from December 2024 to September 2025. All the patients were categorized
into three groups; Group-I euthyroid controls (n=40), Group-II subclinical hypothyroidism (n=40), and clinical hypothyroidism
(n=40). Blood sample was taken and analyzed for lipid profiles and thyroid functions. Lipid profiles, Thyroid
function tests, and body mass index (BMI) recorded for each individual. SPSS v28 used for statistical analysis.
Results: Of the total 120 patients, there were 18 (15%) male and 102 (85%) female. The overall mean age (years) and
BMI (Kg/m2) were 29.88±5.89 and 29.68 (25-34), respectively. Both hypothyroid groups showed higher levels of lipid
profiles compared to euthyroid controls (p<0.01), with the clinical hypothyroid group showing the highest levels. Lower
HDL-C levels observed in hypothyroid groups, but the difference was not statistically significant. Lipid profile and body
mass index showed a positive correlation in both hypothyroid groups, especially in clinical group.
Conclusion: The present study observed that increased body mass index and variations in lipid profile in hypothyroidism
are established risk factors. Subclinical hypothyroidism exhibits lower BMI and dyslipidemia than clinical hypothyroidism,
underling the routine BMI monitoring and lipid profile measurement to manage cardiovascular disease risk at earliest.
Keywords: Hypothyroidism, Subclinical Hypothyroidism, Lipid Profile, Body Mass Index, Dyslipidemia, Cardiovascular
Risk.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Journal of Muhammad Medical College (J Muhammad Med Coll) belief that all researches are basically conducted for the benefit of humanity. Research is the product of an investment by society and consequently its fruits should be returned in a transparent fashion to all humankind without any discrimination.
Journal of Muhammad Medical College is an open access journal which means that all content is freely available without charge to users or / institution. When used non-commercially all users are allowed to read, download, copy, distribute, print, search, or link to full text articles in this journal without asking prior permission from the publisher or author as long as original author(s) are acknowledged.
Journal of Muhammad Medical College operate under Creative Common License CC-BY-SA that allow reproduction of articles free of charge, for non-commercial use only and with the appropriate citation information. All authors publishing with Journal of Muhammad Medical College accept these as the terms of publication.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License